Research in this high-profile area is guided by theories and models from the fields of health science, health economics and epidemiology, hence methodological expertise is required from various disciplines. For instance, the Competence Center for Clinical Trials Bremen (KKSB) and the Leibniz Institute for Prevention Research and Epidemiology (BIPS) develop and refine statistical and biometric methods with a special focus on topics from the high profile area. Exposure assessment methods are investigated inter alia at BIPS and made available within the high-profile area KKSB, BIPS, the Institute of Public Health and Care Research (IPP) and SOCIUM – Research Center on Inequality and Social Policy (formerly ZeS) contribute with their expertise in the planning, implementation, data processing and evaluation of studies. The IPP also provides expertise in the area of qualitative methods. Health economic theories and methods are addressed at SOCIUM and by the Cooperative Research Group for Evidence-Based Public Health (EBPH). The IPP develops models, for example in the fields of nursing science and evidence-based public health. Moreover, SOCIUM and BIPS have a long and successful track record in routine data research, which is carried out intensively at both institutions. This interdisciplinary approach is a major strength of the high-profile area and makes a significant contribution to its theoretical foundation.